Desferrithiocin analogue iron chelators: iron clearing efficiency, tissue distribution, and renal toxicity
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چکیده
منابع مشابه
Desferrithiocin: A Search for Clinically Effective Iron Chelators
The successful search for orally active iron chelators to treat transfusional iron-overload diseases, e.g., thalassemia, is overviewed. The critical role of iron in nature as a redox engine is first described, as well as how primitive life forms and humans manage the metal. The problems that derive when iron homeostasis in humans is disrupted and the mechanism of the ensuing damage, uncontrolle...
متن کاملA comparative study of the iron-clearing properties of desferrithiocin analogues with desferrioxamine B in a Cebus monkey model.
A comparative study of the iron-clearing properties of subcutaneously administered desferrioxamine B (DFO) with those of orally administered desferrithiocin sodium salt (1), desmethyl desferrithiocin (2), desazadesmethyl desferrithiocin sodium salt (3), desazadesmethyl desferrithiocin pivaloyloxymethyl ester (4), and desazadesmethyl-5,5-dimethyl desferrithiocin (5) in an iron-loaded Cebus monke...
متن کاملThalassemia: cardiac iron and chelators.
1. Díez JJ, Iglesias P. The role of the novel adipocyte-derived hormone adiponectin in human disease. Eur J Endocrinol. 2003;148:293-300. 2. Leth H, Andersen KK, Frystyk J, Tarnow L, Rossing P, Paeving HH, et al. Elevated levels of high-molecularweight adiponectin in type 1 diabetes. J Clin Endocrinol Metab. 2008;93:3186-91. 3. Oh DK, Ciaraldi T, Henry RR. Adiponectin in health and disease. Dia...
متن کاملIron, Cancer, Chelators and Rice Bran
Age is the primary risk factor for cancer. Most skin cancers occur after age 50. Most cases of prostate and breast cancer occur after age 65. The Merck Manual says that "although cancer occurs in persons of every age, it is fundamentally a disease of aging. Sixty percent of new cancer cases and two-thirds of cancer deaths occur in persons over 65 years of age." Aging is accompanied by an accumu...
متن کاملIron toxicity
During the past half century, excessive/misplaced iron has been observed to be a risk factor for an increasing number and diversity of disease conditions. An extensive list of conditions and of the types of iron association were published in early 2008. Within the subsequent year, four additional disorders have been recognized to be enhanced by iron: aging muscle atrophy, viral replication, ros...
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ژورنال
عنوان ژورنال: BioMetals
سال: 2010
ISSN: 0966-0844,1572-8773
DOI: 10.1007/s10534-010-9389-y